Thiadiazole, an important heterocyclic ring system, have recently attracted medical science to a great extent because of its diversified biological activities such as anti microbial, anti fungal, anti cancer, anti tubercular, anti HIV, anti convulsant, anti viral, anti inflammatory, anti depressant, anti leishmanial, anti oxidant and many more. In this review we have focused on diversified biological activities and different synthetic routes of 1,3,4-thiadiazole nucleus.
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